| Celkem nalezeno: 62 záznamů |
Keough D., Petrová M., King G., Kratochvíl M., Pohl R.,
Doleželová E.,
Panicucci Zíková A., Guddat L., Rejman D. (2024) Development of prolinol containing Inhibitors of Hypoxanthine-Guanine-Xanthine phosphoribosy itransferase: rational structure-based drug design Journal of Medicinal Chemistry
67: 7158–7175.
DOI: 10.1021/acs.jmedchem.4c00021
|
Kovářová J., Moos M., Barrett M., Horn D.,
Panicucci Zíková A. (2024) The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis PLoS Neglected Tropical Diseases
18: e0012007.
DOI: 10.1371/journal.pntd.0012007
|
Lukeš J., Speijer D.,
Panicucci Zíková A., Alfonzo J.,
Hashimi H.,
Field M. (2023) Trypanosomes as a magnifying glass for cell and molecular biology Trends in Parasitology
39: 902–912.
DOI: 10.1016/j.pt.2023.08.004
Dokumenty ke stažení:
Lukes_2023_TrendsParasitol (pdf)
|
Taleva G.,
Husová M.,
Panicucci B.,
Hierro-Yap C., Pineda E., Biran M., Moos M., Butter F., Šimek P., Bringaud F.,
Panicucci Zíková A. (2023) Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation PLoS pathogens
19: e1011699.
DOI: 10.1371/journal.ppat.1011699
|
Valach M., Benz C., Aguilar L.C.,
Gahura O.,
Faktorová D.,
Zíková A., Oeffinger M., Burger G., Gray M.,
Lukeš J. (2023) Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway Nucleic Acids Research
51: 6443–6460.
DOI: 10.1093/nar/gkad422
Dokumenty ke stažení:
Valach_2023_NucAcidRes (pdf)
|
Wong J.,
Panicucci Zíková A.,
Gahura O. (2023) The ancestral shape of the access proton path of mitochondrial ATP synthases revealed by a split subunit-a Molecular Biology and Evolution
40: msad146.
DOI: 10.1093/molbev/msad146
Dokumenty ke stažení:
Wong 2023 MolBiolEvol (pdf)
|
Arbon D., Ženíšková K., Šubrtová K. , Mach J., Štursa J., Machado M., Zahedifard F. , Leštinová T.,
Hierro-Yap C., Neuzil J., Volf P., Ganter M., Zoltner M.,
Panicucci Zíková A., Werner L., Sutak R. (2022) Repurposing of MitoTam: novel anti-cancer drug candidate exhibits potent activity against major protozoan and fungal pathogens Antimicrobial Agents Chemotherapy
66: 8.
DOI: 10.1128/aac.00727-22
|
Gahura O.,
Chauhan P.,
Panicucci Zíková A. (2022) Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids Trends in Parasitology
38: 1053-1067.
DOI: 10.1016/j.pt.2022.08.010
Dokumenty ke stažení:
Gahura 2022 TrendsParasitol (pdf)
|
Gahura O., Mühleip A.,
Hierro-Yap C.,
Panicucci B.,
Jain M., Hollaus D.,
Slapničková M.,
Panicucci Zíková A., Amunts A. (2022) An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases Nature Communications
13: 5989.
DOI: 10.1038/s41467-022-33588-z
Dokumenty ke stažení:
Gahura 2022 NatCommun (pdf)
|
Klejch T., Keough D., King G.,
Doleželová E., Česnek M., Buděšínský M.,
Panicucci Zíková A., Janeba Z., Guddat L., Hocková D. (2022) Stereo-defined acyclic nucleoside phosphonates are selective and potent inhibitors of parasite 6-oxopurine phosphoribosyltransferases Journal of Medicinal Chemistry
65: 4030–4057.
DOI: 10.1021/acs.jmedchem.1c01881
|
Lemke C., Jílková A., Ferber D., Braune A., On A., Johe P.,
Panicucci Zíková A., Schirmeister T., Mareš M., Horn M., Gütschow M. (2022) Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain Chemistry-A European Journal
28: e202201636.
DOI: 10.1002/chem.202201636
|
Panicucci Zíková A. (2022) Mitochondrial adaptations throughout the Trypanosoma brucei life cycle Journal of Eukaryotic Microbiology
69: e12911.
DOI: 10.1111/jeu.12911
|
Štěpánek O., Čmoková A., Procházková E. , Grobárová V., Černý J.,
Slapničková M.,
Panicucci Zíková A., Kolařík M., Baszczyňski O. (2022) Piperazine-Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens ChemMedChem
17: e202200385.
DOI: 10.1002/cmdc.202200385
|
Vaňková K.,
Doleželová E., Tloušťová E., Hocková D.,
Panicucci Zíková A., Janeba Z. (2022) Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase European Journal of Medicinal Chemistry
239: 114559.
DOI: 10.1016/j.ejmech.2022.114559
|
Cadena L.,
Gahura O.,
Panicucci B.,
Panicucci Zíková A.,
Hashimi H. (2021) Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae mSphere
16: e0032721.
DOI: 10.1128/mSphere.00327-21
Dokumenty ke stažení:
Cadena_2021_mSphere (pdf)
|
Doleželová E., Klejch T., Špaček P., Slapničková M., Guddat L., Hocková D.,
Zíková A. (2021) Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro Scientific Reports
11: 13317.
DOI: 10.1038/s41598-021-91747-6
|
Gahura O.,
Hierro-Yap C.,
Zíková A. (2021) Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthase Parasitology
148: 1151–1160.
DOI: 10.1017/S0031182021000202
|
Hierro-Yap C., Šubrtová ,
Gahura O.,
Panicucci B., Dewar C., Chinopoulos C., Schnaufer A.,
Zíková A. (2021) Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei Journal of Biological Chemistry
296: 100357.
DOI: 10.1016/j.jbc.2021.100357
|
Kalčic F., Frydrych J.,
Doleželová E.,
Slapničková M., Pachl P., Slavětínská L.P., Hocková D.,
Zíková A., Janeba Z. (2021) C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase European Journal of Medicinal Chemistry
225: 113798.
DOI: 10.1016/j.ejmech.2021.113798
|
Nguyen V.H., Tichý M., Rožánková S., Pohl R.,
Doleželová E., Tloušťová E.,
Slapničková M.,
Zíková A., Hocek M. (2021) Synthesis and anti-trypanosomal activity of 3'-fluororibonucleosides derived from 7-deazapurine nucleosides Bioorganic & Medicinal Chemistry Letters
40: 127957.
DOI: 10.1016/j.bmcl.2021.127957
|
