RNDr. Martin Palus, Ph.D.
Job Position: Head of Laboratory - Laboratory of Arbovirology
Phone:
+420 387775145
E-mail:
palus@paru.cas.cz
Room:
313c/324
Research interests
My research activity is the study of human viral infections, disease development and its treatment options.
Interest is focused on tick-borne encephalitis virus and related viruses transmitted by ticks and mosquitoes, as well as other viruses that require attention, such as SARS-CoV2.
Education
Faculty of Science, University of South Bohemia in Ceske Budejovice, Czech Republic
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2012-2016 |
Ph.D. (hons.) |
Infectious Biology |
Tick-borne encephalitis – from pathogenesis to therapy |
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2015 |
RNDr. |
Clinical Biology |
Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system |
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2009-2012 |
MSc. |
Clinical Biology |
The role of the host genetic background on the pathogenesis of tick-borne encephalitis |
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2007-2009 2006-2009 |
BSc. (hons.) |
Biology Biology-Biomedical Laboratory Techniques |
Study of the pathogenesis of tick-borne encephalitis in hosts with different genetic and immunological background |
Employment
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2014-present: |
Researcher |
Emerging Viral Diseases, Veterinary Research Institute, Brno, Czech Republic |
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2011-present: |
Head of Lab |
Laboratory of Arbovirology Institute of Parasitology, Biology Centre, Czech Academy of the Sciences |
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2011-2012: |
Assistant |
Laboratory of Biological Monitoring and Protection, The National Institute for Nuclear, Chemical and Biological Protection, Czech Republic |
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2009: |
Assistant |
Dept. of Parasite Immunology , Institute of Parasitology, Biology Centre, Czech Academy of the Sciences |
Research Funding (PI)
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2023 |
Neuropathogenesis linked to NS1 protein of tick-borne encephalitis virus; The Czech Science Foundation (GACR); (2023 - 2025) |
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2022 |
Verification of the possibility of using a mouse antibody against the protein of the tick-borne encephalitis virus for the purposes of diagnosis of tick-borne encephalitis by the ELISA method; Technology Agency of the Czech Republic GAMA2; |
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2020: |
Neurovascular unit cells interactions leading to the blood-brain barrier breakdown during tick-borne encephalitis; The Czech Science Foundation (GACR); (2020 - 2022) |
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2020: |
Identification and characterization of TBEV-neutralizing and cross-reactive antibodies from individuals that are convalescent from flaviviral infection; Programme for research and mobility support of starting researchers from Czech Academy of Sciences (2020-2021) |
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2017: |
Programme of Support of Postdoctoral Fellowships from Czech Academy of Sciences (2017-2018) |
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2015: |
Role of the human brain microvascular endothelial cells during tick-borne encephalitis virus infection in the central nervous system; Grant Agency of the University of South Bohemia |
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2014: |
Role of the human non-neural cells in the neuronal injury during tick-borne encephalitis; Grant Agency of the University of South Bohemia in Ceske Budejovice |
Postgraduate Courses and Internships
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2020-2021: |
Internship: Immunology and Infectious Disease (Davide Robbiani), Institute for Research in Biomedicine, Switzerland |
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2014: |
PREDEMICS, National Institute for Infectious Diseases “L. Spallanzani” – Rome: Workshop on zoonotic features of viral infections from the animal reservoir to pandemic emergence |
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2012: |
Institute of Postgraduate Education in Medicine in Prague: Methods in Laboratory Medicine (accredited qualification course) |
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2011: |
Erasmus Programme: Arbovirus Pathogenesis Group, The Roslin Institute and Royal (Dick)School of Veterinary Studies, The University of Edinburgh (4 mos.) |
Honors
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2021: |
Prize by the President of Czech Academy of Sciences for young scientists for outstanding results |
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2018: |
Otto Wichterle's Award for selected, exceptionally high-quality and promising scientists from the Czech Academy of Sciences |
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2017: |
Dean’s Award for excellent scientific results during Ph.D. studies. Faculty of Science, University of South Bohemia |
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2015: |
Award for the best Czech and Slovak young microbiologist of the year (Czechoslovak Society for Microbiology; XXIV. Tomasek Days of young microbiologists, Brno) |
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2013: |
Best poster award (Moscow, “Chumakov IPVE” RAMS, Up-to-date problems of TBE) |
Publications
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ORCID ID: 0000-0002-4279-7092 |
WoS RID: N-1263-2017 |
Scopus Author ID=25825507600 |
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Selected conferences contribution (talk/poster)
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2023 |
15th International Symposium on Ticks and Tick-borne Diseases; Germany, Weimar (invited) |
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2022 |
10th Tick and Tick-Borne Pathogen Conference, Murighiol, Romania |
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2022 |
Konference: Národní institut virologie a bakteriologie, Czech Republic, Kutná Hora |
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2022 |
XXIV. Hradecké virologické dny, Czech Republic, Hradec Králové |
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2022 |
24th International Symposium on Signal Transduction at the Blood-Brain Barriers, Bari, Italy |
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2019: |
22nd International Symposium on Signal Transduction at The Blood-Brain Barriers, Germany, Würzburg |
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2019: |
The 67th Annual Meeting of the Japanese Society for Virology, Japan, Tokyo |
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2019: |
Joint CzechoSlovak Virology Conference 2019 and 1st SK-AT Structural Virology Meeting, Bratislava |
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2018: |
21nd International Symposium on Signal Transduction at the Blood Brain Barriers, Romania, Arad |
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2018: |
28. Pečenkovy epidemiologické dny, České Budějovice |
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2017: |
Tick and Tick-borne Pathogens 9 (One Health), Australia, Cairns |
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2017: |
Joint CzechoSlovak Virology Conference 2017, České Budějovice |
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2015: |
International Symposium on Flaviviruses: Structure and Immunity, Austria, Vienna |
Selected applied research
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0550809 - FZÚ 2022 RIV CZ cze L - Prototyp, funkční vzorek Antifoulingový povrch biočipu s terpolymerní vrstvou postmodifikovanou specifickou protilátkou pro kvantitativní stanovení viru SARS-CoV-2 v klinických vzorcích pomocí metody QCM. |
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0555327 - BC 2022 RIV cze P1 - Užitný vzor, průmyslový vzor Sada primerů pro amplifikační kontrolu pro detekci koronaviru SARS-CoV-2 metodou izotermické amplifikace LAMP a kit pro detekci koronaviru SARS-CoV-2 metodou izotermické amplifikace LAMP. |
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0542199 - FZÚ 2022 RIV CZ cze L - Prototyp, funkční vzorek Ultra-rezistentní povrch biočipu s terpolymerní vrstvou postmodifikovanou specifickou protilátkou pro rychlou detekci viru SARS-CoV-2 pomocí metody QCM. |
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0537039 - FZÚ 2021 RIV CZ cze L - Prototyp, funkční vzorek Funkční biočip s ultra-rezistentní polymerní vrstvou pro rychlou detekci viru SARS-CoV-2 pomocí metody QCM. |
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O - Ostatní výsledky, 2015, Detection of tick-borne encephalitis virus subtypes by RT-qPCR; Předkladatel: Státní ústav jaderné, chemické a biologické ochrany, v.v.i., Dodavatel: MV0 - Ministerstvo vnitra |
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O - Ostatní výsledky, 2015, Virus Serotyping by TaqMan and SYTO 9 in Single Reaction; Předkladatel: Státní ústav jaderné, chemické a biologické ochrany, v.v.i., Dodavatel: MV0 - Ministerstvo vnitra |
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O - Ostatní výsledky, 2014, Flavivirus Detection by Quantitative PCR; Předkladatel: Státní ústav jaderné, chemické a biologické ochrany, v.v.i., Dodavatel: MV0 - Ministerstvo vnitra |
Other
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Member of the International Brain Barriers Society (IBBS) |
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Member of the World Society for Virology (WSV) |
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Member of the Czechoslovak Society for Microbiology |
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Member of the Scientific Council of Institute of Parasitology, Biology Centre CAS |
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Certificate for the sex and gender dimension of biomedical research completed Libra course |
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Certificate for the performance of diagnostic methods and preparation of medications (Institute for Postgraduate education in Medicine, Prague) |
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Certificate of competency according to § 15d of the Act No. 246/1992 coll. on Protection Animals against Cruelty in present statues at large. Czech University of Life Sciences in Prague, Central commission for Animal Welfare (CCAW) |
| Total found: 45 records
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Prančlová V.,
Hönig V.,
Zemanová M.,
Růžek D., Palus M. (2024) Robust CXCL10/IP-10 and CCL5/RANTES production induced by tick-borne Encephalitis virus in human brain pericytes despite weak infection International Journal of Molecular Sciences
25
: 7892. DOI: 10.3390/ijms25147892 |
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Prančlová V.,
Nedvědová L.,
Kotounová E.,
Hönig V.,
Dvořáková M.,
Davídková M.,
Bílý T.,
Vancová M.,
Růžek D., Palus M. (2024) Unraveling the role of human microglia in tick-borne encephalitis virus infection: insights into neuroinflammation and viral pathogenesis Microbes and Infection
26
: 105383. DOI: 10.1016/j.micinf.2024.105383 |
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Bianchini F., Crivelli V., Abernathy M.E., Guerra C., Palus M., Muri J., Marcotte H., Piralla A., Pedotti M. , de Gasparo R., Simonelli L., Matkovic M., Toscano C., Biggiogero M., Calvaruso V.,
Svoboda P., Cervantes Rincón T., Fava T., Podešvová L., Shanbhag A.A., Celoria A., Sgrignani J., Štefánik M.,
Hönig V.,
Prančlová V., Michalcikova T., Procházka J., Guerrini G., Mehn D., Ciabattini A., Abolhassani H., Jarrossay D., Uguccioni M., Medaglini D., Pan-Hammarström Q., Calzolai L., Fernandez D. , Baldanti F., Franzetti-Pellanda A., Garzoni C., Sedlacek R.,
Růžek D., Varani L., Cavalli A., Barnes C.O., Robbiani D.F. (2023) Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein Science Immunology
8
: eade0958. DOI: 10.1126/sciimmunol.ade0958 |
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Fořtová A., Barkhash A.V., Pýchová M., Krbková L., Palus M.,
Salát J.,
Růžek D. (2023) Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis Journal of NeuroVirology
29
: 699–705. DOI: 10.1007/s13365-023-01182-8 |
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Fořtová A.,
Hönig V.,
Salát J., Palus M., Pýchová M., Krbková L., Barkhash A.V., Kříha M.F., Chrdle A., Lipoldová M.,
Růžek D. (2023) Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients Virus Research
324
: 199020. DOI: 10.1016/j.virusres.2022.199020 |
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Kevély Á.,
Prančlová V., Sláviková M.,
Haviernik J.,
Hönig V., Nováková E., Palus M.,
Růžek D., Klempa B., Koči J. (2023) Fitness of mCherry reporter tick-borne encephalitis virus in tick experimental models Viruses-Basel
14
: 2673. DOI: 10.3390/v14122673 |
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Pilipenco A., Forinová M., Mašková H.,
Hönig V., Palus M., Scott L.N., Víšová I., Vrabcová M., Houska M., Anthi J., Spasovová M., Mustacová J.,
Štěrba J., Dostálek J., Tung C.P., Yang A.S., Jack R., Dejneka A., Hajdu J., Vaisocherová-Lísalová H. (2023) Negligible risk of surface transmission of SARS-CoV-2 in public transportation Journal of Travel Medicine
30
: taad065. DOI: 10.1093/jtm/taad065 |
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Ribeiro J.,
Hartmann D.,
Bartošová-Sojková P., Debat H., Moos M., Fara J., Šimek P., Palus M.,
Kučera M.,
Hajdušek O.,
Sojka D.,
Kopáček P.,
Perner J. (2023) Blood-feeding adaptations and virome assessment of the poultry red mite Dermanyssus gallinae guided by RNA-seq Communications Biology
6
: 517. DOI: 10.1038/s42003-023-04907-x |
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Salát J., Huňady M.,
Svoboda P., Strelcova L.,
Straková P., Fořtová A., Palus M.,
Růžek D. (2023) Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs Vaccine
41
: 6150-6155. DOI: 10.1016/j.vaccine.2023.09.019 |
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Svoboda P., Haviernik J., Bednar P., Matkovic M., Cervantes Rincón T., Keeffe J., Palus M.,
Salát J., Agudelo M., Nussenzweig M.C., Cavalli A., Robbiani D.F.,
Růžek D. (2023) A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody Cell Reports
42
: 113149. DOI: 10.1016/j.celrep.2023.113149 |
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Fořtová A.,
Hönig V., Palus M.,
Salát J., Pýchová M., Krbková L.,
Vyhlídalová T., Kříha M.F., Chrdle A.,
Růžek D. (2022) Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis Journal of General Virology
103
: 1743. DOI: 10.1099/jgv.0.001743 |
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Kovacech B., Fialova L., Filipcik P., Skrabana R., Zilkova M., Paulenka-Ivanovova N., Kovac A., Palova D., Paulikova Rolkova G., Tomkova K., Turic Csokova N., Markova K., Skrabanova M., Sinska K., Basheer N., Majerova P., Hanes J., Parrak V., Prcina M., Cehlar O., Cente M., Piestansky J., Fresser M., Novák M., Sláviková M., Borsova K., Cabanova V., Brejová B., Vinař T., Nosek J., Klempa B.,
Eyer L.,
Hönig V., Palus M.,
Růžek D.,
Vyhlídalová T.,
Straková P., Mrazkova B., Zudova D., Koubkova G,, Novosadova V., Procházka J., Sedlacek R., Zilka N., Kontsekova E. (2022) Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern Ebiomedicine
76
: 103818. DOI: 10.1016/j.ebiom.2022.103818 |
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Migné C.V.,
Hönig V., Bonnet S.I., Palus M., Rakotobe S., Galon C., Heckmann A.,
Výletová E., Devillers E., Attoui H.,
Růžek D., Moutailler S. (2022) Evaluation of two artificial infection methods of live ticks as tools for studying interactions between tick-borne viruses and their tick vectors Scientific Reports
12
: 491. DOI: 10.1038/s41598-021-04498-9 |
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Agudelo M., Palus M., Keeffe J., Bianchini F., Svoboda P.,
Salát J., Peace A., Gazumyan A., Cipolla M., Kapoor T., Guidetti F., Yao K.H.,
Elsterová J., Teislerová D., Chrdle A.,
Hönig V., Oliveira T., West A.P., Lee Y.E., Rice C.M., MacDonald M.R., Bjorkman P.J.,
Růžek D., Robbiani D.F., Nussenzweig M.C. (2021) Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease. Journal of Experimental Medicine
218
: e20210236. DOI: 10.1084/jem.20210236 |
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Beliavskaia A.,
Hönig V.,
Erhart J.,
Vyhlídalová T., Palus M., Černý J., Kozlova I.,
Růžek D., Palomar A.M., Bell-Sakyi L. (2021) Spiroplasma Isolated From Third-Generation Laboratory Colony Ixodes persulcatus Ticks. Frontiers in Veterinary Science
8
: 659786. DOI: 10.3389/fvets.2021.659786 |
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de Gasparo R., Pedotti M., Simonelli L., Nickl P., Mueckschh F., Cassaniti I., Percivalle E., Lorenzi J.C.C., Mazzola F., Magrì D., Michalcikova T.,
Haviernik J.,
Hönig V., Mrazkova B., Polakova N., Fortova A., Tureckova J., Iatsiuk V., Di Girolamoa S., Palus M., Zudova D., Bednar P., Bukova I., Bianchini F., Mehni D., Nencka R.,
Straková P., Pavlis O., Rozman J., Gioria S., Sammartino J.C., Giardina F., Gaiarsak S., Hammarström Q.P., Barnes C.O., Bjorkmann P.J., Calzola L., Piralla A., Baldanti F., Nussenzweig M.C., Bieniasz P.D., Hatziioannouh T., Procházka J., Sedlacek R., Robbiani D.F.,
Růžek D., Varani L. (2021) Bispecific antibody neutralizes SARS-CoV-2 variants, protects mice from disease and prevents escape Nature
593
: 424–428. DOI: 10.1038/s41586-021-03461-y |
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Forinová M., Pilipenco A., Víšová I., Lynn N.S., Dostálek J.,
Mašková H.,
Hönig V., Palus M.,
Selinger M., Kočová P., Dycka F., Štěrba J., Houska M., Vrabcová M., Horak P., Anthi J., Tung C.P., Yu C.M., Chen C.Y., Huang Y.C., Tsai P.H., Lin S.Y., Hsu H.J., Yang A.S., Dejneka A., Vaisocherová-Lísalová H. (2021) Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples ACS Applied Materials and Interfaces
50
: 60612–60624. DOI: 10.1021/acsami.1c16930 |
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Haviernik J.,
Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E.,
Růžek D. (2021) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research
185
: 104968. DOI: 10.1016/j.antiviral.2020.104968 |
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Petry M., Palus M., Leitzen E., Mitterreiter J.G., Huang B., Kröger A., Verjans G.M.G.M., Baumgärtner W., Rimmelzwaan G.F.,
Růžek D., Osterhaus A., Prajeeth C.K. (2021) Immunity to TBEV related flaviviruses with reduced pathogenicity protects mice from disease but not from TBEV entry into the CNS Vaccines
9
: 196. DOI: 10.3390/vaccines9030196 |
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Salát J., Huňady M., Schanilec P.,
Straková P., Štefánik M.,
Svoboda P., Strelcova L., Bojcukova J., Palus M.,
Růžek D. (2021) Experimental and natural infections of tick-borne encephalitis virus in dogs Viruses-Basel
13
: 2039. DOI: 10.3390/v13102039 |
