Mgr. Ondřej Gahura, Ph.D.

Job Position: Head of Laboratory - Laboratory of Evolution of Molecular machines

Contact details

Phone: +420 38777 5433
E-mail: gahura@paru.cas.cz
Room: nová budova 5. patro

Description

In our research we combine approaches of structural biology (cryoEM) and biochemistry with homology identification, structure modeling and phylogenetic analyses to gain insight into function, biogenesis and evolution of macromolecular complexes in endosymbiotic organelles, mitochondria and plastids.

More details available here.

Ondrej Gahura on ResearchGate

 

 

Curriculum vitae

2024 - present           Group Leader, Institute of Parasitology, Biology Centre CAS, Ceske Budejovice

2013 - 2024               Postdoctoral associate, Institute of Parasitology, Biology Centre CAS, Ceske Budejovice (Dr. A. Zikova)

2013-2017                 Visiting scientist, Mitochondrial Biology Unit, MRC, Cambridge, UK (Sir John Walker, 18 months in total)

2012                          Research associate, Faculty of Science, University of Geneva, Switzerland (Prof. F. Stutz, 3 months)

2006-2012                 Research assistant, Faculty of Science, Charles University in Prague, Czech Republic (Dr. P. Folk)

2012                          Ph.D. in Molecular and Cell Biology, Genetics and VirologyCharles University in Prague, Czech Republic (Dr. P. Folk)

2006                          M.Sc. in Biological SciencesFaculty of Science, Charles University in Prague, Czech Republic (Dr. P. Folk)

 

Teaching Epigenetics and Gene Expression Regulation
Faculty of Science, University of South Bohemia

Introduction to OMICS and Biotechnology
Faculty of Science, University of South Bohemia

Publications
Total found: 26 records
Abrhámová K., Groušlová M., Valentová A., Hao X., Liu B., Převorovský M., Gahura O., Půta F., Sunnerhagen P., Folk P. (2024) Truncating the spliceosomal ‘rope protein’ Prp45 results in Htz1 dependent phenotypes RNA Biology 21 : 1–17.
DOI: 10.1080/15476286.2024.2348896

Documents to download:
Abrhamova 2024 RNABiol (pdf)
Afonin D.A., Gerasimov E.S., Škodová-Sveráková I., Záhonová K., Gahura O., Albanaz A.T.S., Myšková E., Bykova A., Paris Z., Lukeš J., Opperdoes F.R., Horváth A., Zimmer S., Yurchenko V. (2024) Blastocrithidia nonstop mitochondrial genome and its expression are remarkably insulated from nuclear codon reassignment Nucleic Acids Research 50 : 3870–3885.
DOI: 10.1093/nar/gkae168

Documents to download:
Afonin_2024_NAR (pdf)
Pecina P., Čunátová K., Kaplanová V., Puertas-Frias G., Šilhavý J., Tauchmannová K., Vrbacký M., Čajka T., Gahura O., Hlaváčková M., Stránecký V., Kmoch S., Pravenec M., Houštěk J., Mráček T., Pecinová A. (2024) Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome Communications Biology 7 : 1116.
DOI: 10.1038/s42003-024-06819-w

Documents to download:
Pecina 2024 CommsBiology (pdf)
Sheikh S., Pánek T., Gahura O., Týč J., Záhonová K., Lukeš J., Eliáš M., Hashimi H. (2023) A novel group of dynamin-related proteins shared by eukaryotes and giant viruses is able to remodel mitochondria from within the matrix Molecular Biology and Evolution 40 : msad134.
DOI: 10.1093/molbev/msad134

Documents to download:
Sheikh_2023_MolBiolEvol (pdf)
Valach M., Benz C., Aguilar L.C., Gahura O., Faktorová D., Zíková A., Oeffinger M., Burger G., Gray M., Lukeš J. (2023) Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway Nucleic Acids Research 51 : 6443–6460.
DOI: 10.1093/nar/gkad422

Documents to download:
Valach_2023_NucAcidRes (pdf)
Wong J., Panicucci Zíková A., Gahura O. (2023) The ancestral shape of the access proton path of mitochondrial ATP synthases revealed by a split subunit-a Molecular Biology and Evolution 40 : msad146.
DOI: 10.1093/molbev/msad146

Documents to download:
Wong 2023 MolBiolEvol (pdf)
Zakharova A., Saura A., Morales J., Tashyreva D., Butenko A., Svobodová M., Poschmann G., Nandipati S., Zakharovová A., Noyvert D., Gahura O., Týč J., Stühler K., Kostygov A., Nowack E.C.M., Lukeš J., Yurchenko V. (2023) A neo-functionalized homolog of host transmembrane protein controls localization of bacterial endosymbionts in the trypanosomatid Novymonas esmeraldas Current Biology 33 : 2690-2701.
DOI: 10.1016/j.cub.2023.04.060

Documents to download:
Zakharova_2023_CB (pdf)
Gahura O., Chauhan P., Panicucci Zíková A. (2022) Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids Trends in Parasitology 38 : 1053-1067.
DOI: 10.1016/j.pt.2022.08.010

Documents to download:
Gahura 2022 TrendsParasitol (pdf)
Gahura O., Mühleip A., Hierro-Yap C., Panicucci B., Jain M., Hollaus D., Slapničková M., Panicucci Zíková A., Amunts A. (2022) An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases Nature Communications 13 : 5989.
DOI: 10.1038/s41467-022-33588-z

Documents to download:
Gahura 2022 NatCommun (pdf)
Cadena L., Gahura O., Panicucci B., Panicucci Zíková A., Hashimi H. (2021) Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae mSphere 16 : e0032721.
DOI: 10.1128/mSphere.00327-21

Documents to download:
Cadena_2021_mSphere (pdf)
Gahura O., Hierro-Yap C., Zíková A. (2021) Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthase Parasitology 148 : 1151–1160.
DOI: 10.1017/S0031182021000202
Hierro-Yap C., Šubrtová , Gahura O., Panicucci B., Dewar C., Chinopoulos C., Schnaufer A., Zíková A. (2021) Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei Journal of Biological Chemistry 296 : 100357.
DOI: 10.1016/j.jbc.2021.100357
Tobiasson V., Gahura O., Aibara S., Baradaran R., Panicucci Zíková A., Amunts A. (2021) Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit Embo Journal e106292.
DOI: 10.1101/2020.06.28.176446
Lukeš J., Danek P., Alejo-Valle O., Potůčková E., Gahura O., Heckl D., Stárková J., Starý J., Mejstříková E., Alberich-Jorda M., Zuna J., Trka J., Klusmann J.-H., Zaliová M. (2020) Chromosome 21 gain is dispensable for transient myeloproliferative disorder driven by a novel GATA1 mutation Leukemia 34 : 2503-2508.
DOI: 10.1038/s41375-020-0769-1
Gahura O., Panicucci Zíková A. (2019) Isolation of F1-ATPase from the Parasitic Protist Trypanosoma brucei Journal of visualized experiments : JoVE 22 : e58334.
DOI: 10.3791/58334
Nenarokova A., Záhonová K., Krasilnikova M., Gahura O., McCulloch R., Zíková A., Yurchenko V., Lukeš J. (2019) Causes and effects of loss of classical nonhomologous end joining pathway in parasitic eukaryotes mBio 10 : e01541-19.
DOI: 10.1128/mBio.01541-19

Documents to download:
Nenarokova_et al._2019 (pdf)
Doleželová E., Terán D., Gahura O., Kotrbová Z., Procházková M., Keough D., Špaček P., Hocková D., Guddat L., Zíková A. (2018) Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery PLOS Neglected Tropical Diseases DOI: 10.1371/journal.pntd.0006301
Gahura O., Panicucci B., Váchová Hana, Walker John E., Zíková A. (2018) Inhibition of F1 -ATPase from Trypanosoma brucei by its regulatory protein inhibitor TbIF1 FEBS Journal DOI: 10.1111/febs.14672
Gahura O., Šubrtová , Váchová Hana, Panicucci B., Fearnley Ian M., Harbour Michael E., Walker John E., Zíková A. (2018) The F1 -ATPase from Trypanosoma brucei is elaborated by three copies of an additional p18-subunit FEBS Journal 285 : 614-628.
DOI: 10.1111/febs.14364
Montgomery M.G., Gahura O., Leslie A.G., Zíková A., Walker J.E. (2018) ATP synthase from Trypanosoma brucei has an elaborated canonical F1-domain and conventional catalytic sites. Proceedings of the National Academy of Sciences of the United States of America 115 : 2102-2107.
DOI: 10.1073/pnas.1720940115

More publications

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

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