HR Excellence in Science

Mgr. Eva Doleželová, Ph.D.

Maiden:Pavlová

Job Position: Professional staff - Laboratory of Functional Biology of Protists

Contact details

Phone: +420 387775429
E-mail: dolezelova@paru.cas.cz
Room: PARU II, 2.05

Curriculum vitae

UNIVERSITY STUDIES

  • 1995-1998: Faculty of Biological Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic, Bachelor of Biology
  • 1998-2000: Faculty of Biological Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic, Master degree in genetics and genetic engineering
  • 2000: Special chancellor’s award for excellent study
  • 2000-2004: Faculty of Biological Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic, Ph.D program in molecular and cell biology and genetics 
  • 2011-present: Faculty of Educational Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic, Bachelor program 

SCIENTIFIC ACTIVITIES AND POSITIONS

  • 2001-2005: Research Scientist, Biology Centre AS CR, Institute of Entomology, Ceske Budejovice 
  • 2001: 10 months research stay in Prof. Peter J. Bryant laboratory, Developmental Biology Center, University of California, Irvine, USA
  • 2003: 3 months research stay in Prof. Peter Bryant lab, Developmental Biology Center, University of California, Irvine, USA. 
  • 2005-2007: Postdoctoral position in Prof. Jeffrey C. Hall, Brandeis University, Waltham, MA, USA

PUBLICATIONS:

  • Zurovec M, Dolezal T, Gazi M, Pavlova E, Bryant PJ. Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine.Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4403-8. Epub 2002 Mar 19.
  • Moreira CK, Capurro Mde L, Walter M, Pavlova E, Biessmann H, James AA, deBianchi AG, Marinotti O. Primary characterization and basal promoter activity of two hexamerin genes of Musca domestica. J Insect Sci. 2004;4:2. Epub 2004 Feb 3.
  • Dolezelova E, Zurovec M, Dolezal T, Simek P, Bryant PJ. The emerging role of adenosine deaminases in insects. Insect Biochem Mol Biol. 2005 May;35(5):381-9. Review.
  • Dolezal T, Dolezelova E, Zurovec M, Bryant PJ. A role for adenosine deaminase in Drosophila larval development. PLoS Biol. 2005 Jul;3(7):e201. Epub 2005 May 24.
  • Dolezelová E, Zurovec M, Böhmová M, Sehnal F. Use of two transcription starts in the G6PD gene of the bark beetle Ips typographus. Insect Mol Biol. 2006 Feb;15(1):25-32.
  • Dolezelova E, Nothacker HP, Civelli O, Bryant PJ, Zurovec M. A Drosophila adenosine receptor activates cAMP and calcium signaling.Insect Biochem Mol Biol. 2007 Apr;37(4):318-29. Epub 2007 Jan 5.
  • Dolezelova E, Dolezel D, Hall JC. Rhythm defects caused by newly engineered null mutations in Drosophila's cryptochrome gene.Genetics. 2007 Sep;177(1):329-45. Epub 2007 Aug 24.
  • Hall JC, Chang DC, Dolezelova E. Principles and problems revolving around rhythm-related genetic variants.Cold Spring Harb Symp Quant Biol. 2007;72:215-32. Review.
  • Knight D, Harvey PJ, Iliadi KG, Klose MK, Iliadi N, Dolezelova E, Charlton MP, Zurovec M, Boulianne GL. Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila. J Neurosci. 2010 Apr 7;30(14):5047-57.

PRESENTATIONS: 

  • Pavlova E. (2000): Molecular genetic markers as powerful tools to analyse genetic diversity of spruce bark beetle (Ips typographus). Proceedings of conference about spruce bark beetle. In Czech (Abstract in English). 
  • Zurovec M., Pavlova E., Gazi M., Dolezal T., Bryant P. J.: Adenosine deaminase-related growth factors (ADGFs) stimulate cell proliferation by depleting extracellular adenosine. 43rd Annual Drosophila Research Conference, April 10 - 14, 2002, San Diego, CA, USA.
  • Dolezal T., Gazi M., Pavlova E., Bryant P. J., Zurovec.M.: Mutations affecting Adenosine Deaminase-related Growth Factors (ADGFs) mimic the response to juvenile hormone in Drosophila. Great Barrier Reef Drosophila Conference, July 12 - 17, 2003, Cairns, Australia
  • Dolezal T., Dolezelova E., Bryant P. J.: The role of adenosine deaminase in innate immunity of Drosophila.12th International Congress of Immunology and 4th Annual Conference of FOCIS, July 18-23,2004, Montreal, Canada
  • Dolezelova E. and. Zurovec M.: Adenosine Deaminases. XXII. International Congress of Entomology, August 15-21, 2004, Brisbane, Australia.

Publications
Total found: 17 records
Keough D., Petrová M., King G., Kratochvíl M., Pohl R., Doleželová E., Panicucci Zíková A., Guddat L., Rejman D. (2024) Development of prolinol containing Inhibitors of Hypoxanthine-Guanine-Xanthine phosphoribosy itransferase: rational structure-based drug design Journal of Medicinal Chemistry 67 : 7158–7175.
DOI: 10.1021/acs.jmedchem.4c00021
Klejch T., Keough D., King G., Doleželová E., Česnek M., Buděšínský M., Panicucci Zíková A., Janeba Z., Guddat L., Hocková D. (2022) Stereo-defined acyclic nucleoside phosphonates are selective and potent inhibitors of parasite 6-oxopurine phosphoribosyltransferases Journal of Medicinal Chemistry 65 : 4030–4057.
DOI: 10.1021/acs.jmedchem.1c01881
Vaňková K., Doleželová E., Tloušťová E., Hocková D., Panicucci Zíková A., Janeba Z. (2022) Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase European Journal of Medicinal Chemistry 239 : 114559.
DOI: 10.1016/j.ejmech.2022.114559
Doleželová E., Klejch T., Špaček P., Slapničková M., Guddat L., Hocková D., Zíková A. (2021) Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro Scientific Reports 11 : 13317.
DOI: 10.1038/s41598-021-91747-6
Kalčic F., Frydrych J., Doleželová E., Slapničková M., Pachl P., Slavětínská L.P., Hocková D., Zíková A., Janeba Z. (2021) C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase European Journal of Medicinal Chemistry 225 : 113798.
DOI: 10.1016/j.ejmech.2021.113798
Nguyen V.H., Tichý M., Rožánková S., Pohl R., Doleželová E., Tloušťová E., Slapničková M., Zíková A., Hocek M. (2021) Synthesis and anti-trypanosomal activity of 3'-fluororibonucleosides derived from 7-deazapurine nucleosides Bioorganic & Medicinal Chemistry Letters 40 : 127957.
DOI: 10.1016/j.bmcl.2021.127957
Perlíková P., Krajczyk A., Doleželová E., Slapničková M., Milisavljevic N., Slavětínská L.P., Tloušt'ová E., Gurská S., Džubák P., Hajdúch M., Panicucci Zíková A., Hocek M. (2021) Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides ACS Infectious Diseases 7 : 917–926.
DOI: 10.1021/acsinfecdis.1c00062
Doleželová E., Kunzová M., Dejung M., Levin M., Panicucci B., Regnault C., Janzen C., Barrett M.P., Butter F., Panicucci Zíková A. (2020) Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei Plos Biology 18 : e3000741.
DOI: 10.1371/journal.pbio.3000741
Smith J.T., Doleželová E., Tylec B., Bard J.E., Chen R., Sun Y., Panicucci Zíková A., Read L. (2020) Developmental regulation of edited CYb and COIII mitochondrial mRNAs is achieved by distinct mechanisms in Trypanosoma brucei Nucleic Acids Research 48 : 8704–8723.
DOI: 10.1093/nar/gkaa641
Terán D., Doleželová E., Keough D., Hocková D., Panicucci Zíková A., Guddat L. (2019) Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP FEBS Journal 286 : 4721-4736.
DOI: 10.1017/S0022149X19000737
Doleželová E., Terán D., Gahura O., Kotrbová Z., Procházková M., Keough D., Špaček P., Hocková D., Guddat L., Zíková A. (2018) Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery PLOS Neglected Tropical Diseases DOI: 10.1371/journal.pntd.0006301
Knight D., Harvey P., Iliadi K., Klose M., Iliadi N., Doleželová E., Charlton M., Žurovec M., Boulianne G. (2010) Equilibrative Nucleoside Transporter 2 Regulates Associative Learning and Synaptic Function in Drosophila. The Journal of Neuroscience 30 : 5047-5057.
Doleželová E., Doležel D., Hall J. (2007) Rhythm defects caused by newly engineered null mutations in Drosophila’s cryptochrome gene. Genetics 177 : 329-345.
DOI: 10.1534/genetics.107.076513

Documents to download:
Dolezelova et al. (2007) (pdf)
Doleželová E., Nothacker P., Civelli O., Bryant P., Žurovec M. (2007) A Drosophila adenosine receptor activates cAMP and calcium signaling. Insect Biochemistry and Molecular Biology 37 : 318-329.
Doleželová E., Žurovec M., Böhmova M., Sehnal F. (2006) Use of two transcription starts in the G6PD gene of the bark beetle Ips typographus. Insect Mol Biol. 15 : 25-32.
Doležal T., Doleželová E., Žurovec M., Bryant P. (2005) A role for adenosine deaminase in Drosophila larval development. PLoS Biology 3 : 1213-1224.
Doleželová E., Žurovec M., Doležal T., Šimek P., Bryant P. (2005) The emerging role of adenosine deaminases in insects. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 35 : 381-389.

CONTACT

Biology Centre CAS
Institute of Parasitology
Branišovská 1160/31
370 05 České Budějovice

 

Phone: +420 387 775 403
E-mail: paru@paru.cas.cz

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