Job Position: Statutory representative
,
Head of Laboratory
-
Laboratory of Functional Biology of Protists
Phone:
+420 387775482
E-mail:
azikova@paru.cas.cz
Room:
PARU II, 2.06
Current Position:
2009 – now Group leader, Institute of Parasitology, Biology Centre ASCR, České Budějovice, Czech Republic
2013 - now Lecturer, University of SOuth Bohemia, Faculty of Science, České Budějovice, Czech Republic
2013 & 2016 2 maternity leaves
Professional Experience:
2011 research stay supported by EMBO short fellowship at the MRC Mitochondrial Biology Unit, Cambridge, UK; hosting lab: John E. Walker laboratory (6 weeks)
2005 – 2009 postdoctoral scientist, Seattle Biomedical Research Institute, Seattle, USA
2004 – 2005 research stay supported by NATO fellowship at the Seattle Biomedical Research Institute, Seattle, USA; hosting lab: prof. Ken Stuart (6 months)
2001 research stay, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; hosting lab: prof. Rob Benne (3 months)
Education and Academic Qualification:
2006 Ph.D. in Molecular Parasitology, Department of Parasitology, University of South Bohemia, Faculty of Biological Sciences, České Budějovice, Czech Republic
2002 M.Sc. - Master in Parasitology (Cum Laude), University of South Bohemia, Faculty of Biological Sciences, České Budějovice
Honors and Awards received:
2010 Otto Wichterle Prize of the Academy of Sciences of the Czech Republic
2009 L’Oréal National Fellowship For Women In Science
2007 Outstanding PhD thesis, Dean Award, Faculty of Biological Sciences, České Budějovice, Czech Republic
Biochemie a molekulární biologie parazitů / Biochemistry and molecular biology of parasites
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia
Advanced Methods in Molecular Biology
Faculty of Science, University of South Bohemi
Molekulární biologie / Molecular Biology of Cell
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia
Keough D., Petrová M., King G., Kratochvíl M., Pohl R.,
Doleželová E., Panicucci Zíková A., Guddat L., Rejman D. (2024) Development of prolinol containing Inhibitors of Hypoxanthine-Guanine-Xanthine phosphoribosy itransferase: rational structure-based drug design Journal of Medicinal Chemistry
67
: 7158–7175.
DOI: 10.1021/acs.jmedchem.4c00021
|
Kovářová J., Moos M., Barrett M., Horn D., Panicucci Zíková A. (2024) The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis PLoS Neglected Tropical Diseases
18
: e0012007.
DOI: 10.1371/journal.pntd.0012007
|
Lukeš J., Speijer D., Panicucci Zíková A., Alfonzo J.,
Hashimi H.,
Field M. (2023) Trypanosomes as a magnifying glass for cell and molecular biology Trends in Parasitology
39
: 902–912.
DOI: 10.1016/j.pt.2023.08.004
Documents to download:
Lukes_2023_TrendsParasitol (pdf)
|
Taleva G.,
Husová M.,
Panicucci B.,
Hierro-Yap C., Pineda E., Biran M., Moos M., Butter F., Šimek P., Bringaud F., Panicucci Zíková A. (2023) Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation PLoS pathogens
19
: e1011699.
DOI: 10.1371/journal.ppat.1011699
|
Valach M., Benz C., Aguilar L.C.,
Gahura O.,
Faktorová D., Zíková A., Oeffinger M., Burger G., Gray M.,
Lukeš J. (2023) Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway Nucleic Acids Research
51
: 6443–6460.
DOI: 10.1093/nar/gkad422
Documents to download:
Valach_2023_NucAcidRes (pdf)
|
Wong J., Panicucci Zíková A.,
Gahura O. (2023) The ancestral shape of the access proton path of mitochondrial ATP synthases revealed by a split subunit-a Molecular Biology and Evolution
40
: msad146.
DOI: 10.1093/molbev/msad146
Documents to download:
Wong 2023 MolBiolEvol (pdf)
|
Gahura O.,
Chauhan P., Panicucci Zíková A. (2022) Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids Trends in Parasitology
38
: 1053-1067.
DOI: 10.1016/j.pt.2022.08.010
Documents to download:
Gahura 2022 TrendsParasitol (pdf)
|
Gahura O., Mühleip A.,
Hierro-Yap C.,
Panicucci B.,
Jain M., Hollaus D.,
Slapničková M., Panicucci Zíková A., Amunts A. (2022) An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases Nature Communications
13
: 5989.
DOI: 10.1038/s41467-022-33588-z
Documents to download:
Gahura 2022 NatCommun (pdf)
|
Klejch T., Keough D., King G.,
Doleželová E., Česnek M., Buděšínský M., Panicucci Zíková A., Janeba Z., Guddat L., Hocková D. (2022) Stereo-defined acyclic nucleoside phosphonates are selective and potent inhibitors of parasite 6-oxopurine phosphoribosyltransferases Journal of Medicinal Chemistry
65
: 4030–4057.
DOI: 10.1021/acs.jmedchem.1c01881
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Lemke C., Jílková A., Ferber D., Braune A., On A., Johe P., Panicucci Zíková A., Schirmeister T., Mareš M., Horn M., Gütschow M. (2022) Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain Chemistry-A European Journal
28
: e202201636.
DOI: 10.1002/chem.202201636
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Panicucci Zíková A. (2022) Mitochondrial adaptations throughout the Trypanosoma brucei life cycle Journal of Eukaryotic Microbiology
69
: e12911.
DOI: 10.1111/jeu.12911
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Štěpánek O., Čmoková A., Procházková E. , Grobárová V., Černý J.,
Slapničková M., Panicucci Zíková A., Kolařík M., Baszczyňski O. (2022) Piperazine-Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens ChemMedChem
17
: e202200385.
DOI: 10.1002/cmdc.202200385
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Vaňková K.,
Doleželová E., Tloušťová E., Hocková D., Panicucci Zíková A., Janeba Z. (2022) Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase European Journal of Medicinal Chemistry
239
: 114559.
DOI: 10.1016/j.ejmech.2022.114559
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Cadena L.,
Gahura O.,
Panicucci B., Panicucci Zíková A.,
Hashimi H. (2021) Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae mSphere
16
: e0032721.
DOI: 10.1128/mSphere.00327-21
Documents to download:
Cadena_2021_mSphere (pdf)
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Doleželová E., Klejch T., Špaček P., Slapničková M., Guddat L., Hocková D., Zíková A. (2021) Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro Scientific Reports
11
: 13317.
DOI: 10.1038/s41598-021-91747-6
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Gahura O.,
Hierro-Yap C., Zíková A. (2021) Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthase Parasitology
148
: 1151–1160.
DOI: 10.1017/S0031182021000202
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Hierro-Yap C., Šubrtová ,
Gahura O.,
Panicucci B., Dewar C., Chinopoulos C., Schnaufer A., Zíková A. (2021) Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei Journal of Biological Chemistry
296
: 100357.
DOI: 10.1016/j.jbc.2021.100357
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Kalčic F., Frydrych J.,
Doleželová E.,
Slapničková M., Pachl P., Slavětínská L.P., Hocková D., Zíková A., Janeba Z. (2021) C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase European Journal of Medicinal Chemistry
225
: 113798.
DOI: 10.1016/j.ejmech.2021.113798
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Nguyen V.H., Tichý M., Rožánková S., Pohl R.,
Doleželová E., Tloušťová E.,
Slapničková M., Zíková A., Hocek M. (2021) Synthesis and anti-trypanosomal activity of 3'-fluororibonucleosides derived from 7-deazapurine nucleosides Bioorganic & Medicinal Chemistry Letters
40
: 127957.
DOI: 10.1016/j.bmcl.2021.127957
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Perlíková P., Krajczyk A.,
Doleželová E.,
Slapničková M., Milisavljevic N., Slavětínská L.P., Tloušt'ová E., Gurská S., Džubák P., Hajdúch M., Panicucci Zíková A., Hocek M. (2021) Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides ACS Infectious Diseases
7
: 917–926.
DOI: 10.1021/acsinfecdis.1c00062
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